Abstract

In the present study an intermolecular reductive Schiff base formation from nitro derivative and benzaldehydes is carried out in the presence of iron powder and dilute acid. Schiff base has been synthesized from 2-thiophenecarboxyldehyde and 2-nitro benzoic acid. Metal complexes of the Schiff base were also prepared from salts of Mn (II) and Co (II) in an alcoholic medium. The chemical structures of the Schiff-base ligand and its metal complexes were confirmed by various spectroscopic studies. The free Schiff base and its complexes have been tested for their antibacterial as well as antifungal activity by using disc diffusion method and the results discussed. The experimental results suggest that Schiff base derivatives are more potent in antibacterial and antifungal activities.

Keywords

Schiff base, 2-thiophenecarboxyldehyde, 2-nitro benzoic acid, Metal complexes, Antibacterial activity, Antifungal activity

Cite This Article

Prasad, A. V. G. S., Rao, V. A., & Prasad, P. S. S. (2014). Spectral and Biological studies of Manganese (II) and Cobalt (II) Complexes with Schiff Base Derived from 2-Thiophenecarboxylaldehyde and 2-nitrobenzoic Acid. International Journal for Pharmaceutical Research Scholars, 3(1), 91-94.