Abstract

A series of five novel azetidinones were synthesized by cyclocondensation of various Schiff bases of naphthylamine with Chloroacetylchloride in the presence of triethylamine. Schiff’s bases preparing from naphthylamine moiety by reacting the hydrazide of the parent compound with different aromatic or heterocyclic aldehydes under acidic conditions in ethanol and cyclocondensation of Schiff’s bases with chloracetyl chloride in the presence of triethylamine and dioxane resulted in the formation of corresponding azetidinone derivatives. The newly synthesized compounds were characterized by IR, and mass spectra. The synthesized compounds were evaluated for antibacterial and antifungal activities by Agar diffusion method. All the compounds at a concentration of 1000,500,250,125 and 62.5μg/ml and compounds were screened for their antibacterial activity against Staphylococcus,aureus, Bacillus subtilis (Gram positive bacteria) Escherichia coli, Pseudomonas aeruginosa (Gram-negative bacteria) by disk diffusion method. Compounds showed good anti-bacterial activity against Staphylococcus aureus and Bacillus subtilis. Compounds SAz1 -5 exhibited good antifungal activity against Candida albicans fungus.

Keywords

Azetidinones, Naphthylamine, Anti-bacterial, Anti-fungal

Cite This Article

Pandya, K. M., & Desai, P. S. (2013). Study on Synthesis of Some Novel Azetidinone Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 179-183.