Abstract

1-chloro-4-(p-tolyolxy)benzene react with 1-(4-hydrogy phenyl)-ethanone in presence of copper metal as a catalyst gives 1-(4-(4(p-tolyolxy) phenoxy)phenyl) ethanone, this derivatives react with various substituted aldehyde to give corresponding substituted chalcone derivatives. Now these derivatives on condensation with 2-aminobenzenethiol gives the vast range of thiazepine derivatives. Structure elucidation of synthesized compound has been made on the basis of element analysis, 1H NMR Spectra studies. The microbial activity of the synthesized compounds has been studied against the species bacillus subtillis, staphylococcus aureus, Escherichia coli, and salmonella typhi.

Keywords

Synthesis, Heterocyclic substituted chalcone derivatives, Pyrimidine derivatives, Chalcones

Cite This Article

Dave, H., & Vyas, K. B. (2014). Study on Synthesis of Some Novel Thiazepine Derivatives their Antimicrobial Activity. International Journal for Pharmaceutical Research Scholars, 3(1), 86-90.