Abstract

A series of novel 1-acetyl-5-(aryl)-{3-[4-(2-phenyl-4-p-methoxybenzylidene-5-oxo-imidazol-1- yl)]phenyl}-4,5-dihydropyrazoles was synthesized by the reaction of 4-(4-methoxybenzylidene)-1-{4-[3-(aryl)prop-2-enoyl]phenyl}-2-phenyl-imidazol-5-ones with hydrazine hydrate followed by reaction with acetic acid. All the newly synthesized 1-acetyl pyrazoles were characterized by different spectroscopic techniques and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity.

Keywords

Chalcone, Hydrazine Hydrate, 1-Acetyl Pyrazole, Antibacterial Activity, Antifungal Activity

Cite This Article

Shah, R. A.,Nimavat, K. S., & Dodiya, D. K. (2016). Synthesis and Antimicrobial Evaluation of 1-Acetylpyrazole Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 196-200.