Synthesis and Antiulcer, Anti-secretory Activity of Some New substituted 2-(Pyrimidinylsulfinyl) Benzimidazoles Derivatives

Author(s)

Khan, F. R.

Author's Affiliation

Abstract

A series of all new substituted 2-(pyrimidinylsulfinyl) benzimidazoles derivatives synthesized from different starting material and evaluation against antiulcer and antisecretory activity as a inhibition of gastric H+/K+- ATPase by induction of gastric ulcerations experimentally in male Wister rats according to the method. The newly synthesized compounds were characterized by IR and elemental analysis. All compounds were tested for antiulcer and antisecretory activities. The antiulcer activities of the compounds were assessed by Acetylsalicylic acid (ASA) method-induced gastric ulcer.

Keywords

Antiulcer and Antisecretory Activity, 2-Pyrimidinylsulfinyl, Benzamidazoles

Cite This Article

Khan, F. R. (2014). Synthesis and Antiulcer, Anti-secretory Activity of Some New substituted 2-(Pyrimidinylsulfinyl) Benzimidazoles Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 1-7.