Abstract

The purpose of this study is based upon synthesis of a series of 1,4-disubstituted piperazine derivatives through two step reaction. This protocol involves the formation of various mannich base derivatives (N-01 to N-07) through reaction in which microwave synthesis is carried out to prepare 1-phenyl piperazine The second step involves the reaction of 1-phenyl piperazine (N-01 to N-07) with substituted aniline to afford target compounds. (N-01 to N-o7). The structures of target compounds were elucidated from the data of the different spectral methods of analysis. In addition, a mass spectrum, for a representative example, was carried out where the expected fragmentation pattern is in accordance with the structure of the proposed compound. The anthelmintic activity of the synthesized derivatives (N-01 to N-07) was investigated in vitro against Eisenia fetida. All the investigational compounds (N-01 to N-07) and) exhibited promising anthelmintic activity at minimal dose of 5mg/ml in comparison with reference drug Piperazine citrate.

Keywords

1-Phenyl Piperazine, Anthelmintic Activity, Mannich Base, Anthelmintic Activity

Cite This Article

Panchal, N.B., Captain, A.D. (2015). Synthesis and Screening of Some New Piperazine Derivatives as Potential Anthelmintic Agents, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 26-37.