Abstract

The present work reports the possible utility of the synthesis of some novel 4-(2-amino-3-cyano-4-(substituted-aryl)-5- oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl)benzene sulfonamide (1a–1u) starting with 4-(3-oxo-cyclohex- 1-enylamino)benzenesulfonamide and 4-(cyclohexenylamino) benzenesulfonamide in the synthesis of some novel 4-(quinolin-1-yl) benzenesulfonamide derivatives. The structures of the synthesized compounds were confirmed by IR, ¹H NMR, ¹³C NMR and mass spectral data. Some of the newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity.

Keywords

Synthesis, sulfonamide, cyclohexanone 1, 3 dione, antibacterial, antifungal

Cite This Article

Rathod, C. P., Dhawale, S. C., Pekamwar, S. S., Kadam, N. R., & Rekhawar, M. U. (2012). Synthesis, Characterization, Antimicrobial and Antifungal Screening of Some Novel Benzene Sulfonamide Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 1(4), 146-155.