Abstract

Synthesis of a series of 4-hydroxy-6-methyl-3-(substituted methyl)-2H-chromen-2-one. (4a-g) was achieved from different secondary amine, formaldehyde and 4-hydroxy-6-methyl-2H-chromen-2-one using Con HCl added and refluxed within 8 hrs with good yield. The structures of the products were supported by FTIR, PMR and mass spectral data.

Keywords

4-hydroxy-6-methyl-3-(substituted methyl)-2H-chromen-2-one; secondary amine, 2-Aformaldehyde, only refluxed

Cite This Article

Karia, D. C., Pancholi, K. S., & Varu, R. A. (2013). Synthetic Advances and Biological Activities of 4-Hydroxy Coumarin Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 139-142.