Received On: 13/06/2014
Accepted On: 24/06/2014
Wankhede, D. S., Wagh, P. B., Rajput, S. B., Karuppayil, S. M., Satare, S. S.
A series of seven macrocyclic complexes is synthesized by template condensation of diethyl malonate and malonyldihydrazide in methanolic medium in the presence of transition metal ions such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II). The synthesized complexes have been characterized with the help of molar conductance, magnetic susceptibility measurements, IR, electronic, and 1H-NMR Spectra. On the basis of studies made a six coordinated octahedral geometry has been proposed for all these complexes. The synthesized complexes were also screened for their antifungal activity against human fungal pathogen Candida albicans and most of them have been found to exhibit significant antifungal activity.
Diethyl Malonate, Malonyldihydrazide, Template Method, Octahedral, Antifungal Activity
Cite This Article
Wankhede, D. S., Wagh, P.B., Rajput, S. B., Karuppayil, S. M., & Satare, S. S. (2014). Macrocyclic Complexes of Bioactive Divalent and Trivalent Transition Metal Ions Using Diethyl Malonate and Malonyldihydrazide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 766-774.