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Innovations in Transdermal Drug Delivery System – A Review


Received On: 25/02/2012
Accepted On: 28/02/2012


Author(s)

Shah, K.K., Patel, K.N., Patel, H.K., Patel, B.A., Patel, P.A.


Author's Affiliation


Abstract

The number of medications and the ways in which they can be administered have expanded dramatically over the years. One such advance has been the development of transdermal delivery systems. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivery of the drug molecules to the systemic circulation via this route. Various types of transdermal approaches used to incorporate the active ingredients include use of prodrugs/lipophilic analogs, permeation enhancers, sub saturated systems and entrapment into vesicular systems. Innovations in technologies continue to occur at a positive rate, making the technology a fertile and vibrant. This article deals with the innovations in the field of TDDS to improve the release rate and other parameters and most suitable to the patient.


Keywords

Transdermal Drug Delivery, Microblades, Electroporation, Iontophoresis, Sonophoresis, Microneedles, Magnetophoresis


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