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Analytical Method Development, Validation and Simultaneous Estimation of Guaifenesin, Levocetirizine Hydrochloride, and Ambroxol Hydrochloride in Syrup Dosage form by RP-HPLC


Received On: 31/03/2016
Accepted On: 01/4/2016


Author(s)

Konagala, S., Bhauvaneswara, R.C., Priyanka, M.V., Anusha, M., Kalyani, T.


Author's Affiliation


Abstract

In the present study a validated stability indicating RP-HPLC method for quantification of GFS, LCZ and ABX was established. Compared with the reported methods, this method represents the first report about a stability indicating method for the determination of GFS, LCZ and ABX. With the proposed method a satisfactory separation of three drugs from the degradation products and impurities, extended linear range and rapid analysis time were carried out. A high recovery of GFS, LCZ and ABX in formulation was achieved. The proposed method ensured a precise and accurate determination of GFS, LCZ and ABX in formulation. No interference from the excipients was noticed.


Keywords

Guaifenesin, Levocetirizine hydrochloride, Ambroxol hydrochloride, RP HPLC, Validation

Cite This Article

Konagala, S., Bhauvaneswara, R. C., Priyanka, M. V., Anusha, M., Kalyani, T. (2016). Analytical Method Development, Validation and Simultaneous Estimation of Guaifenesin, Levocetirizine Hydrochloride, and Ambroxol Hydrochloride in Syrup Dosage form by RP-HPLC, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 231-258.


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