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Formulation and Evaluation of Prolonged Release Transdermal Drug Delivery System of Telmisartan for the Treatment of Hypertension


Received On: 07/09/2016
Accepted On: 12/09/2016


Author(s)

Singh, A., Singh, P.


Author's Affiliation


Abstract

The objective of the present study was to formulate and evaluate controlled and prolonged release transdermal drug delivery system of Telmisartan for effective management of hypertension. The administration of Telmisartan via transdermal patch facilitates a direct entry of drug molecules into the systemic circulation, avoiding the first-pass metabolism and drug degradation in the harsh gastrointestinal environment, which are often associated with oral administration. To fulfill above objective transdermal patches of Telmisartan were prepared by solvent evaporation method using combinations of Eudragit RL100, Ethyl cellulose and PVP in different proportions. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, water vapour transmission and tensile strength were evaluated. In-vitro Diffusion Study, skin irritation test and stability studies were also performed. In PVA and Eudragit RL 100 patches the water vapor transmission rate was found to be higher at 75% RH, RT conditions. Therefore at both % RH, RT conditions the PVA and Eudragit RL 100 patches provide the best resistance to water vapor.


Keywords

Telmisartan, Eudragit RL100, Ethyl Cellulose, PVP, Transdermal Patch, In-Vitro Permeation Study

Cite This Article

Singh, A., Singh, P. (2016). Formulation and Evaluation of Prolonged Release Transdermal Drug Delivery System of Telmisartan for the Treatment of Hypertension, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(3), 128-134.


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