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Estimation of Ambroxol Hydrochloride and Gold (Iii) by Simple, Visible Spectrophotometry


Received On: 21/12/2013
Accepted On: 28/12/2013


Author(s)

Reddy, S. T., Reddy, K. N., Giri, A.


Author's Affiliation


Abstract

This paper describes a new, simple, accurate, and selective visible spectrophotometric method for the estimation of Ambroxol Hydrochloride in bulk drugs and pharmaceutical dosages. It is a specific method for the determination of Gold (III) in Gold alloys .Gold (III) reacts with Ambroxol in the pH range 1.0-5.0 forming a pink colored complex shows an absorption maximum at 520nm. A study of the colour reaction carried out at pH 2.5. Under the optimum conditions Beer’s law is obeyed in the range 5.0-100.0 µg/ml. The straight line plot obeyed the equation A = 0.0122 C + 0.0019. The correlation coefficient (r) of the experimental data of the calibration plot is 0.9999. The method is applied successfully for the determination of Ambroxol in pharmaceutical formulation. Keeping Ambroxol in excess, Au (III) is determined. Beer’s law is obeyed in the range 2.0-40.0 µg/ml of Au (III). The straight line plot obeyed the equation A = 0.0243 C + 0.0007. The correlation coefficient (r) of the experimental data of the calibration plot is 0.9999.The effect of various foreign ions associated with Au (III) is studied. The method is applied for the determination of Au (III) in Egyptian gold alloy. The developed method was validated according to ICH guidelines and was found to be accurate and precise. The validation parameters are linearity, accuracy, precision, LOD, LOQ and Ruggedness are studied. Thus the proposed method can be successfully applied for the estimation of Ambroxol and Gold (III).


Keywords

Ambroxol, Au (III), Visible spectrophotometric determination, Method validation

Cite This Article

Reddy, S. T., Reddy, K. N., & Giri, A. (2013). Estimation of Ambroxol Hydrochloride and Gold (Iii) by Simple, Visible Spectrophotometry. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 378-385.


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