Malathi, V., Manivasakam, M., Mohammed, M. M., Parthiban, P.
Siddha system of medicine is simple practical traditional, sasthric and bearing the cultural heritage of India. Siddha medicines have significant amount of heavy metals. It was propounded that hazardous effect of heavy metals would cause toxic accumulation. Based on mode of preparation, Indian system of medicine documented safe usage of drugs since 2500 years. Kirubakara Shanmuga Chenduram (KSC), a siddha medicine contains mostly metallic ingredients. In this study we have evaluated toxicity of KSC in Wistar albino rats. The acute and 28 days repeated oral toxicity study was done according to OECD guidelines 423 and 407 respectively. In acute study, high dose 2000mg/kg/bw of drug was produced neurotoxic symptoms but there were no remarkable changes in 28 days repeated oral toxicity study. Haematological and biochemical parameters did not show any change. In quantitative analysis (ICP-OES), the heavy metals like lead, cadmium, arsenic was found in BDL and mercury was found in 0.317 ppm. In histopathology study brain, heart, lungs, kidney, liver, spleen did not show any pathology. So KSC was toxic only in high dose of 2000 mg/kg. It reveals that the therapeutic dose of KSC (202mg- thuvarai alavu) is the safe dose for clinical use for human being.
Kirubakara Shanmuga Chenduram, Toxicity, Siddha Medicine, OECD Guideline
Cite This Article
Malathi, V., Manivasakam, M., Mohammed, M. M., & Parthiban, P. (2014). Acute Toxicity and 28 Days Repeated Oral Toxicity Study of a Siddha Medicine Kirubagara Shanmuga Chenduram in Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 347-354.