Lasan, V.M., Patel, S.A.
A simple, specific and accurate high performance liquid chromatographic method was developed for the Escitalopram Oxalate in pharmaceutical dosage form. The column used was Inertsil ODS-2 (250 x 4.6 mm, 5µm) with mobile phase containing buffer, Acetonitrile and Methanol (670:280:50 v/v/v). The buffer is prepared by adding 3.4gm of potassium dihyrogen phosphate in a 1000ml of volumetric flask with water. Add 1ml of triethylamine. Adjust the pH to 3.8 with diluted Orthophosphoric acid solution. Filter with nylon 0.45 µm it. The flow rate was 1.0 ml/ min and effluents were monitored at 238 nm. The retention times of Escitalopram Oxalate were found to be 14 min. The proposed method was validated and successfully applied to the estimation of Escitalopram Oxalate in pharmaceutical dosage forms.
Escitalopram Oxalate, Buffer, Acetonitrile, Methanol, Validation
Cite This Article
Lasan, V.M., Patel, S.A. (2015). Analytical Method Development and Method Validation for Escitalopram Oxalate in Pharmaceutical Dosage Forms by HPLC Method, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 19-25.