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Home Article Analytical Method Development and Validation of Lamotrigine by High Performance Liquid Chromatography


Research Article

Analytical Method Development and Validation of Lamotrigine by High Performance Liquid Chromatography


Author(s)

Murthy, A. R., Babu, K. R., Vekariya, N.A.


Author's Affiliation


Abstract

In the present work, a rapid and sensitive RP-HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine in Bulk and in Pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (70:30 v/v) with flow rate 1.1 ml min-l. In the range of 20-100 μg/ml, the linearity of Lamotrigine shows a correlation co-efficient of 0.9998. Recovery of drug was found to be good (99-102%). Method was found to be reproducible with relative standard deviation (RSD) values less than 2% for intra and inter- day precision. The proposed method was validated as per the standard guidelines.


Keywords

Lamotrigine, bulk, formulation, HPLC


Cite This Article

Murthy, A. R., K. Babu, K. R., & Vekariya, N.A. (2014). Analytical Method Development and Validation of Lamotrigine by High Performance Liquid Chromatography. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 155-161.


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