Antidiabetic and Hypolipidemic Activity of Monochoria Vaginalis Presl. On Alloxan Induced Diabetic Rats

Author(s)

Chinna, R. R., Periyasamy, M., Muthukumar, A., Anand, G.

Author's Affiliation

Abstract

The Antidiabetic activity of Monochoria vaginalis presl. (Family: pontederiaceae) was investigated in Alloxan induced diabetic albino rats. The Monochoria vaginalis prel plant has been reported for its analgesic activity, nephrotoxic, antioxidant activities and nutritive values, paniya tribe of India used the leaves for diabetes¹⁵ but there are no scientific data is available regarding the effect on the blood glucose levels. So we have made an attempt to use hydroalcoholic extract of Monochoria vaginalis presl leaf (HAEMV) for studying anti-diabetic activity. The dried leaves of Monochoria vaginalis presl. were subjected to extraction by continuous hot percolation using water and ethanol (50 : 50) as solvent and were subjected to standardization using pharmacognostical and phytochemical screening. Dose selection was made on the basis of acute oral toxicity study (200 mg/kg body weight) as per OECD and CPCSEA guidelines. Oral administration of extracts of Monochoria vaginalis presl (200mg/kg, 400mg/kg) for 14 days resulted in a significant reduction in blood glucose levels. The extract also prevented body weight loss in diabetic rats.

Keywords

Alloxan, Monochoria vaginalis, Anti diabetic

Cite This Article

Chinna, R. R., Periyasamy, M., Muthukumar, A., Anand, G. (2013). Antidiabetic and Hypolipidemic Activity of Monochoria Vaginalis Presl. On Alloxan Induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(3), 98-102.