Assessment of Anti-Ulcer Activity of Corbichonia decumbens Forsk. Methanolic Extract by Aspirin plus Pyloric Ligation Model

Author(s)

Uma, G., Balasubramaniam, V., Kumar, S. J.

Author's Affiliation

Abstract

The objective of present study is to evaluate the anti-ulcer activity of methanolic extract of leaf and Root of Corbichonia decumbens. The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanol extract of Corbichonia decumbens leaf and Root were investigated by aspirin plus pylorus ligation induced gastric ulcer in rats.  In aspirin plus pylorus ligation model, Corbichonia decumbens at doses of 200 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. It can be concluded that methanol extract of corbichonia decumbens possesses antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords

Anti-Ulcer, Corbichonia Decumbens, Pylorus Ligation

Cite This Article

Uma, G., Balasubramaniam, V., & Kumar, S. J. (2014). Assessment of Anti-Ulcer Activity of Corbichonia decumbens Forsk. Methanolic Extract by Aspirin plus Pyloric Ligation Model. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 757-761.