Design and In Vitro Evaluation of Sustained Release Matrix Tablets of Levofloxacin by Using Natural and Synthetic Polymers

Author(s)

Chethan, C., Ashok, P., Kulkarni, S.V.

Author's Affiliation

Abstract

Sustain release tablets of Levofloxacin were made up from Aloe verabarbadensis, Karaya gum, Locust bean gum, HPMC K100 and Ethyl cellulose. The results of pre-compression studies revealed that they were within prescribed limits that indicate good flowing property. Physical characteristics like hardness, weight variation, friability and drug content were evaluated. All the formulations were found to be within the official limits. A better-sustained drug release (97.45%) was obtained with the matrix tablet (F-2) of the HPMC K 100 gum for the period of 12 hours. Results showed that the drug release from matrix tablets prepared by using natural polymers could be sustained for more than 10 hrs and the drug release vary with concentration of polymer in matrix tablet. Thermograph of levofloxacin didn't show any interaction between drug and matrix materials. Then value lies between 0.729 to 0.948 (Korsmeyer-Peppa’s model) demonstrating that the mechanism of drug release was Anomalous (non-Fickian) diffusion for the formulations (F-1 to F-15).

Keywords

Matrix Tablet, Levofloxacin, Natural Polymers, Synthetic Polymers

Cite This Article

Chethan, C.,   Ashok, P., Kulkarni, S.V. (2017). Design and In Vitro Evaluation of Sustained Release Matrix Tablets of Levofloxacin by Using Natural and Synthetic Polymers. International Journal for Pharmaceutical Research Scholars (IJPRS), 6(2), 54-64.