Ramesh, B., Rao, L. R., Satyanandam, R., Sai, K. V., Martha, D. A.
Microspheres are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate Losartan potassium microspheres by Emulsification internal gelation method, with water soluble polymers such as Sodium alginate, Guar gum, Xanthan gum and Baco3 as crosslinking agent, using as carrier for oral administration in view to achieve oral controlled release of the drug. Losartan potassium is a Angiotensin II receptor blocker selectively and specifically antagonize the action of angiotensin II, a potent vasoconstrictor impacting BP regulation. Angiotensin II receptor blocker are becoming increasingly popular for the treatment of hypertension because they are effective and well tolerated. It has short biological half-life of 1.5-2 hrs. This necessitates multiple daily dosing for maintenance of its plasma concentration within the therapeutic index, hence there is impetus for developing controlled release dosage form that maintains therapeutic plasma drug concentration for long period. Compatibility studies revealed there was no interaction between the drug and polymers. The formulations were evaluated for particle size distribution analysis, flow properties like Angle of repose, bulk density, tapped density, Hausner’s Ratio, Carr’s index, microencapsulation efficiency, Scanning electron microscopy and in-vitro release studies. The optimized formulation showed good in-vitro controlled release activity of the drug Losartan potassium.
Controlled Release Microspheres, Sodium Alginate, Baco3, Cross Linking Agent, Emulsification Internal Gelation Method
Cite This Article
Ramesh, B., Rao, L. R., Satyanandam, R., Sai, K. V., & Martha, D. A. (2014). Design, Development and In Vitro Evaluation of Controlled Release Microspheres of Losartan Potassium. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 94-101.