Gawai, N. M., Biyani, K. R.
The present investigation is concerned with development and characterization of mucoadhesive buccal tablets containing antihypertensive drug, Metoprolol Succinate to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. The tablets were prepared by direct compression method. Twelve formulations were developed with varying concentrations of polymers like HPMC K-15M, Carbopol 934 P, Sodium CMC and PVP K-30. The tablets were tested for weight variation, hardness, surface pH, drug Content uniformity, swelling index, and bioadhesive strength and in-vitro drug dissolution study. FTIR studies showed no evidence on interactions between drug, polymers, and excipients. The in vitro release of Metoprolol Succinate was performed under sink conditions (Phosphate buffer pH 6.8, 37±0.5ºC, rpm 50) using USP-XXIV dissolution apparatus type II. The in vitro release kinetics studies reveal that all formulations fits well with zero order kinetics followed by Korsmeyer-Peppas, first order and then Higuchi’s model and the mechanism of drug release is non-Fickian diffusion. From the all evaluation test carried for the each buccal tablet formulation of Metoprolol Succinate, it is conclude that, the formulation F 10, in the view of mucoadhesion study, in vitro residence time, drug content uniformity and percentage drug released over 1hr to 20 hr, F 10 was found to be optimized batch.
Metoprolol Succinate, Mucoadhesive, Carbopol 934, HPMC K15M
Cite This Article
Gawai, N. M., & Biyani, K. R. (2014). Development and Characterization of Mucoadhesive Buccal Tablet of Metaprolol Succinate. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 810-816.