Development and Evaluation of Extended Release Formulation of Tramadol Hydrochloride Based on Osmotic Technology

Author(s)

Patel, J. B., Halba, P. D., Patel, K. N., Patel, P. A.

Author's Affiliation

Abstract

Extended release formulation of Tramadol Hydrochloride based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as osmotic agent, plasticizer and coating thickness of semi-permeable membrane were found to markedly affect drug release. Tramadol hydrochloride release was directly proportional to the level of osmogent and plasticizer but inversely proportional to the level of coating thickness of semi-permeable membrane. Drug release from developed formulation was independent of pH and agitation intensity but dependent on osmotic pressure of release media. The optimized formulation was compared with marketed product CONTRAMAL SR and accelerated stability study was also carried out for 6 months.

Keywords

Tramadol hydrochloride, extended release, osmotic pressure

Cite This Article

Patel, J. B., Halba, P. D., Patel, K. N., & Patel, P. A. (2013). Development and Evaluation of Extended Release Formulation of Tramadol Hydrochloride Based on Osmotic Technology. International Journal for Pharmaceutical Research Scholars (IJPRS), 2013, 2(2), 226-234.