Development and Optimization of Osmotically Controlled Oral Drug Delivery System of Aceclofenac

Author(s)

Edavalath, S., Rao, B. P.

Author's Affiliation

Abstract

The aim of the present study is to formulate and optimize porous osmotic pump tablets for controlled delivery of Aceclofenac for the treatment of Arthritis. Drugs can be delivered in a controlled pattern over a long period of time by osmotic technology. The formulation contains drug core and it is coated with semipermeable membrane. The formulation design was done by multilevel categoric factorial design using Design expert software. Solid dispersed form of Aceclofenac was used to improve the solubility of the drug. The dependent variables were considered are concentration of osmotic agent (Potassium chloride), solubility enhancer (Sodium lauryl sulphate) and percentage of weight gain after coating. The core tablets were coated with cellulose acetate (80%) and PEG 4000 (20%). All the formulations were studied for the physiochemical parameters and drug release studies.  Numerical optimization techniques were applied to find the best formulation. The effect of pH, Osmotic pressure, agitation intensity on drug release, membrane morphology and stability studies were performed. The optimized formulation shows stable, physiological properties independent controlled drug delivery of Aceclofenac for the period of 24hours.

Keywords

Aceclofenac, Osmotic pressure, Controlled porosity osmotic pump tablet, Osmogent, Semipermeable membrane

Cite This Article

Edavalath, S. & Rao, B. P. (2014). Development and Optimization of Osmotically Controlled Oral Drug Delivery System of Aceclofenac. International Journal for Pharmaceutical Research Scholars, 3(1), 330-344.