Development and Validation of UV Spectrophotometric Method for the Estimation of Tolvaptan in Bulk and Tablet Dosage Form

Author(s)

Chaudhari, B. G., Patel, C.

Author's Affiliation

Abstract

A simple, rapid, accurate and precise assay procedure based on Spectrophotometric method has been developed for the estimation of Tolvaptan in Pharmaceutical formulation. The method was based on estimation of Tolvaptan at absorption maxiam about 274 nm using methanol as adiluent. The proposed method was linear over the range of 2-20 μg/mL with correlation co-efficient (r²) of 0.998 and mean recovery for tolvaptan was 99.61 %. The intermediate data obtained under different experimental setup, the calculated value of co-efficient of variance (CV, %) was found to be within a limit. The proposed method can be successfully applied for the analysis of Tablet formulation.

Keywords

Spectrophotometry, Tolvaptan, Validation

Cite This Article

Chaudhari, B. G., & Patel, C. (2012). Development and Validation of UV Spectrophotometric Method for the Estimation of Tolvaptan in Bulk and Tablet Dosage Form, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 193-198.