Babitha, T. E., Farooq, S. U., Krishna, V. R., Krishna, M. V., Kumar, D. S.
Timolol maleate is a β- adrenoceptor blocker used in the management of raised blood pressure. The purpose of this research work was to formulate the fast dissolving film of Timolol maleate by solvent casting method for the treatment of hypertension, by using the polymers such as HPC, HPMC E5 and HPMC E15 in different concentration. Poly ethylene glycol 400 was used as plasticizer. Films were subjected for physicochemical characterization evaluation such as thickness, weight uniformity, folding endurance, drug content, surface pH study, in vitro drug release, and stability study. Films were found to be satisfactory when evaluated for thickness, weight uniformity, in-vitro drug release, folding endurance, drug content and disintegration time. The surface pH of all the films was found to be neutral pH. The in vitro drug release in optimized formulation F1 was found 98 % in 10 min. The optimized formulation F4 also showed satisfactory pH, drug content (99%), effective in vitro drug release (96.7% in 15 min), disintegration time in 30sec and satisfactory stability.
Anti-hypertensive; solvent casting technique; hydrophilic polymer; fast dissolving film
Cite This Article
Babitha, T. E., Farooq, S. U., Krishna, V. R., Krishna, M. V., Kumar, D. S. (2014). Development of Fast Dissolving Films of Timolol Maleate : Role of Hydrophillic Polymer. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 830-839.