Evaluation and Screening of Hepatoprotective and Antioxidant Activity of “Mussaenda Frondosa” Root against Paracetamol Induced Hepatotoxicity in Wistar Rats

Author(s)

Thummala, S., Reddy, G. V. K., Rao, Y. N., Rao, M. P.

Author's Affiliation

Abstract

The present research work was an attempt to establish the possible hepatoprotective efficacy using aqueous extract of Mussaenda frondosa root against paracetamol induced hepatotoxicity in rats with an objective to prepare aqueous extract of Mussaenda frondosa roots, then to assess antioxidant property by using In-Vitro methods and to evaluate the hepatoprotective activity against paracetamol induced liver damage in rats by using In-Vivo methods and the following parameters such as Serum glumate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), Serum alkaline phosphate (ALP) and Serum total bilirubin (BIT) are tested from the collected blood of the rats used in the study at the baseline and the end of the dosing, So on comparison of the baseline and the end of the study parameters the results are concluded.

Keywords

Hepatoprotective, Hepatotoxicity, Mussaenda frondosa plant, Antioxidant, Liver damage, Paracetamol, Silymarin

Cite This Article

Thummala, S., Reddy, G. V. K., Rao, Y. N., Rao, M. P. (2013). Evaluation and Screening of Hepatoprotective and Antioxidant Activity of “Mussaenda Frondosa” Root against Paracetamol Induced Hepatotoxicity in Wistar Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(3), 139-145.