Khedekar, D. D., Rachana, S.
Leaves of Psidium Guajava contain flavonoids & phenolic compounds which have been implicated in antidepressant activity. Therefore the present research was aimed to evaluate the potential antidepressant activity of methanolic extract of Psidium Guajava (MEPG) leaves in mice. This extract was administered orally in a dose range of 200 and 400 mg/kg of the body weight. The antidepressant activity was evaluated using tail suspension test (TST), Locomotor activity by Actophotometer and Reserpine antagonism in mice. Results of the activity showed significant decrease in the immobility time in TST & reduction in catalepsy in locomotor activity similar to that of the imipramine (10 mg/kg) and sertraline (20mg/kg). In reserpine antagonism test, the extract showed antagonistic effect on reserpine in tested mice. The significance of difference among the various treated groups and control group were analyzed by means of one-way ANNOVA followed by Dunnett’s Multiple Comparison test. In conclusion, methanolic extract of leaves of Psidium Guajava possesses potential antidepressant activity and has therapeutic potential in the treatment of CNS disorders and provides evidence at least at a preclinical level.
Psidium Guajava Linn, Antidepressant Activity, Tail Suspension Test, Locomotor Activity, Reserpine Antagonism
Cite This Article
Khedekar, D. D., & Rachana, S. (2014). Evaluation of Natural Compounds from Medicinal Plants for Mental Illness. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 64-78.