Evaluation of Protective Effect of Thymoquinone against Anti-tubercular Drug Induced Nephrotoxicity in Rats

Author(s)

Chansoria, A. K., Trivedi, M., Dixit, R. K.

Author's Affiliation

Abstract

Present study was done to see the protective effect of thymoquinone against antitubercular drugs induced nephrotoxicity in rats. Thymoquinone significantly reduced serum urea, serum creatinine and K+ levels in ATT induced renal toxicity. No effect was seen in serum serum Na⁺    level. Higher dose was found to reduce serum urea to greater extent than 5 mg TQ dose. The nephroprotective effect of thymoquinone was found to be significant.  Hence the present study throws light on usefulness of TQ in protection against ATT induced renal injury. This might prove useful for combating the serious renal adverse effects of ATT regimen without eliminating the use of standard first line drugs.

Keywords

Nephrotoxicity, Anti-tubercular drugs, Thymoquinone

Cite This Article

Chansoria, A. K., Trivedi, M., & Dixit, R. K. (2013). Evaluation of Protective Effect of Thymoquinone Against Antitubercular Drug Induced Nephrotoxicity in Rats, International Journal for Pharmaceutical Research Scholars (IJPRS), 2(1), 1-4.