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Home Article Formulation and Evaluation of Bilayered Tablets of Ketorolac Tromethamine and Omeprazole


Research Article

Formulation and Evaluation of Bilayered Tablets of Ketorolac Tromethamine and Omeprazole


Author(s)

Chauhan, N. P., Bhavsar, D. N., Makwana, P. K., Patel, K. B., Brahmbhatt, H. B.


Author's Affiliation


Abstract

The aim and objective of present research study was to formulate and evaluate the bilayered tablets containing Ketorolac Tromethamine floating sustained release layer and Omeprazole as immediate release layer in order to produce a single tablet containing two different classes of drugs widely prescribed by doctors to have better patient compliance and reduced side effects. The sustained release layer of Ketorolac Tromethamine was prepared by wet granulation technique using polymers like HPMC K100M and Carbopol 940 in different concentrations. Sodium bicarbonate was used as a gas generating agent. Immediate release layer of Omeprazole was prepared by wet granulation technique using sodium starch glycolate, Crosspovidone and Crosscarmelose sodium as super disintegrants in different concentrations. Formulated bilayered tablets were characterized for different parameters like hardness, friability, thickness, weight variation, segregation time, disintegration time, floating lag time, total floating time and % Cumulative drug release. The results of the evaluation tests indicated that the optimized formulation SF1 showed desired release along with optimum floating lag time and desired floating lag time for the ketorolac layer and good disintegration time and desired release rate for the omeprazole layer. Also the stability data of the optimized formulation indicated that the formulation showed sufficient stability upon storage.


Keywords

Ketorolac Tromethamine, Omeprazole, Bilayered Floating Tablet


Cite This Article

Chauhan, N. P., Bhavsar, D. N., Makwana, P. K., Patel, K. B., Brahmbhatt, H. B., Jain, H. N., & Upadhyay, U. M. (2014). Formulation and Evaluation of Bilayered Tablets of Ketorolac Tromethamine and Omeprazole. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 10-16.


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