Formulation and Evaluation of Fast Dissolving Tablet of Atenolol

Author(s)

Halkeri, M., Reddy, V.M., Patil, C.C., Kulkarni, R., Girani, S.

Author's Affiliation

Abstract

The objective of this study was to formulate & evaluate Fast dissolving tablet of atenolol. Tablets of Atenolol were prepared by direct compression method using super disintegrants polymers like sodium starch glycolate, croscarmellose sodium, crospovidone in different ratios and their combinations. Fast dissolving tablets were evaluated by different methods for parameters such as thickness, Diameter, hardness, friability, weight variation, drug content, wetting time, In-vitro disintegration time, In-vitro dispersion time, In-vitro drug release, stability studies, drug-excipient compatibility studies like FTIR, DSC. The tablets were evaluated for in vitro release in pH 1.2 phosphate buffer for 30 mins in standard dissolution apparatus. Drug release was increased with increase in the concentration of Crospovidone and their combination with other super disintegrants. In order to determine the mode of release, the data was subjected to Zero order, First order, Higuchi and Peppas diffusion model. Short term stability studies on the promising formulations indicated that there are no significant changes in drug content, hardness, in vitro dissolution characteristics. IR spectroscopic studies indicated that there are no drug-excipient interactions. The prepared fast dissolving tablets of Atenolol could release the drug from tablet within the criteria of fast dissolving tablet.

Keywords

Fast dissolving tablet, Superdisintegrants polymers, Atenolol, Sodium starch Glycolate, Croscarmellose sodium, Crospovidone

Cite This Article

Halkeri, M., Reddy, V.M., Patil, C.C., Kulkarni, R., Girani, S. (2015). Formulation and Evaluation of Fast Dissolving Tablet of Atenolol, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 189-199.