Formulation and Evaluation of Hydrodynamically Balanced Floating Tablet of Biguanide Class Anti-Hypertensive Drug

Author(s)

Thakur, Y., Bhowmick, M., Pandey, G. K., Joshi, A., Dubey, B.

Author's Affiliation

Abstract

Floating  sustained  release dosage forms present  the most of the characteristics of hydrophilic matrices & are known as  ‘hydrodynamically balanced systems’  (‘HBS’)  since  they  are  able  to maintain  their  low  apparent  density, while  the polymer  hydrates &  builds a  gelled  barrier  at  the  outer  surface.  The  drug  is  released progressively  from  the  swollen  matrix,  as  in  the  case  of  conventional  hydrophilic matrices. These forms are expected to remain buoyant (3-4 hours) on the gastric contents without affecting the intrinsic rate of emptying because their bulk density is lower than that of the gastric contents. Hydrodynamically balanced tablets of Metformin have been formulated with an approach to increase gastric residence and thereby improve drug bioavailability. An attempt to develop floating tablets of Metformin, using sodium bicarbonate as gas generating agent and HPMC K4M and xanthin gum as hydrophilic polymer by wet granulation method was achieved. The formulated tablets showed compliance for various preformulation studies and various evaluation parameters like hardness, friability, tablet density, floating test, drug content and in vitro release studies.

Keywords

Hydrodynamically Balanced Tablets, Metformin, HPMC K4M, Xanthin gum

Cite This Article

Thakur, Y., Bhowmick, M., Pandey, G. K., Joshi, A., & Dubey, B. (2013). Formulation and Evaluation of Hydrodynamically Balanced Floating Tablet of Biguanide Class Anti-Hypertensive Drug. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 21-32.