Formulation Development of Eudragit Coated Polymeric Matrices for Targeted and Controlled Delivery to the Colon

Author(s)

Onyechi, J. O., Abali, S. O., Okorie, O.

Author's Affiliation

Abstract

Colon targeted release tablets containing 25-75mg of indomethacin were formulated using Eudragit Coated Polymeric Matrices. Nine batches of indomethacin tablets were prepared containing varying concentrations of Eudragit-S100 (E-S100, 0.94-37.56% w/w), mucin (43.82- 87% w/w), sodium caboxymethyl cellulose (NaCMC, 3-5% w/w) and microcrystalline cellulose (MCC, 9.39% w/w). Batches I-VII granules were prepared using non-aqueous or aqueous/non-aqueous wet granulation methods while batches VIII-IX granules were prepared by dry granulation method. Batches IV-IX tablets were coated with E-S100 or a mixture of E-S100 and Eudragit-L100 to between 4-8% of the tablet weight. Sequential dissolution studies were carried out on the coated tablets in buffer solutions of pH 1.2, 6.8 and 7.2 for 15 hours. Results showed that all the granule samples were compressible except Batch III containing 37.56% w/w of E-S100. Batches VIII and IX Indomethacin tablets coated with 3.76-4.47% w/w of E-S100 exhibited dissolution profiles potentially promising for targeted colonic drug delivery.

Keywords

Targeted Colonic Drug Delivery, Coated Polymeric Devices, Indomethacin

Cite This Article

Onyechi, J. O., Abali, S. O., & Okorie, O. (2014). Formulation Development of Eudragit Coated Polymeric Matrices for Targeted and Controlled Delivery to the Colon. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 475-481.