The present study was conducted to investigate the hepatoprotective effect of Nigella sativa seed oil in ethanol- induced male albino rat. Ethanol was administered to animals for eight weeks to induce liver injury. Ethanol induced rat were treated with N. sativa seed oil at a dose of 5 mL and 10 mL/kg body weight. After eight weeks of treatment, liver function markers, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), albumin level were studied. Antioxidants like, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidise (GPx) and lipid peroxidation were also studied. A significant decrease (p<0.05) in the level of ALT, AST, ALP, GGT and malondialdehyde (MDA) were observed after treatment with 10 mL/kg body weight as compared to ethanol induced. A significant increase (p<,0.05) in the level of CAT, SOD, GPx and albumin level was also observed after the treatment with 10 mL/kg body weight N. sativa oil, in comparison to ethanol intoxicated rat. These results suggest the ameliorating effect of N. Sativa on alcohol induced liver injury by preventing cell membrane disturbances, reduction of oxidative stress by free radical scavenging and antioxidative activity. Thus N. sativa oil can be useful in the treatment of liver damage caused by alcohol.
Hepatoprotective, Nigella sativa, Ethanol-induced, Antioxidative
Cite This Article
Nehar, S. (2014). Hepatoprotective Effect of Nigella sativa Seed Oil on Rat Model of Alcoholic Liver Disease. International Journal for Pharmaceutical Research Scholars, 3(1), 464-472.