Improvement of Solubility by Disintegrating Approach of Poorly Soluble Drugs in Capsule Dosage Form

Author(s)

Pandya, M. N., Patel, T. R., Upadhyay. U. M.

Author's Affiliation

Abstract

Celecoxib belongs to the category of NSAIDS. This drug is used for treatment of rheumatoid arthritis and acute pain during menstruation. Celecoxib is poorly soluble and the intention of the study is to improve the solubility by disintegration approach. Different mixture of disintigrants are used in the preparation of celecoxib by wet granulation method and supplied in gelatin capsule dosage form. Eight different batches are prepared by using different disintigrants in different quantities along with other excipients and then they are evaluated by different parameters. The study demonstrated that celecoxib capsule prepared with various disintegrants showed significantly higher dissolution in comparison with physical powder mixture having same drug excipients ratio. Different mixture of disintigrants is use in the preparation. Out of the disintegration studied Polyplasdone XL 10 grades were superior than the other disintegrates for the drug studied. The combined effect of Polyplasdone XL 10 and cross Carmellose sodium gives better dissolution than individually. So ultimately combined effect of two disintegrants and low grade povidone K30 will give more than 80% dissolution within 30 min.

Keywords

Celecoxib, Disintegrates, Menstruation, Polyplasdone XL 50, Rheumatoid arthritis

Cite This Article

Pandya, M. N., Patel, T. R., & Upadhyay. U. M. (2014). Improvement of Solubility by Disintegrating Approach of Poorly Soluble Drugs in Capsule Dosage Form. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 281-284.