Nagare, R.B., Bhambere, D.S., Kumar, R.S., Kakad, V.K., Nagare, S.N.
Eye is unique and vital organ. It is considered as window of the soul. It suffer from various diseases are treated by topical drug delivery in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability because of dilution low residence time, blurred vision, undesirable side effects arising due to systemic absorption of the drug through naso-lacrimal drainage. To overcome this disadvantages along with consideration of anatomy physiology and biochemistry of eye researchers in ophthalmic drug delivery systems is directed towards a amalgamation of several drug delivery systems, that include to build up systems which not only prolong the contact time of the vehicle at the ocular surface but also slow down the removal of the drug so in situ gel is one of the smart carrier for the sustained and controlled ocular drug delivery. In situ forming ophthalmic hydrogels are liquid upon instillation undergoes phase transition in the ocular cul-de-sac to form visco elastic gel and this provides a response to environmental changes like temperature, ionic strength, ultra violet irradiation or pH. Due to these delivery system reduces disadvantages associated with conventional dosage form and thus serves as best alternative to conventional ophthalmic drops. In this article, an attempt has been made to highlight the reason behind poor bioavailability, concept and importance of in situ gel along with mechanism of gelation with different approaches as well as evaluation parameters.
Poor bioavailability, In-Situ Gel, Phase Transition Systems, Evaluation Parameter
Cite This Article
Nagare, R.B., Bhambere, D.S., Kumar, R.S., Kakad, V.K., Nagare, S.N. (2015). In Situ Gelling System: Smart Carriers for Ophthalmic Drug Delivery, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 10-23.