Microwave Assisted Synthesis & QSAR Study of Some Novel Pyrazole Thioamide Derivatives

Author(s)

Kapase, V. S., Khot, S., Dhongade, S. R.

Author's Affiliation

Abstract

This work involves synthesis of Pyrazole thioamide derivatives from different chalcones 1[a-b] synthesized from substituted   acetophenones and different aromatic aldehydes in basic medium by Claisen Schemidt reaction. These chalcones [1(a-b)] on condensation with different hydrazides [2(a-b)] and isothiocynates [3(a-b)] when irradiated with microwaves (20% 140watts) in scientific microwave oven, give different 2-phenyl-2,5-dihydro-pyrazole-1-carbothioic acid phenyl amide derivatives [4(a-g)]; Library of such pyrazolyl thiazine derivatives has been generated and the structures were subjected to PASS for their probabilities of being active biologically. QSAR study of the library was done to find out most active molecules.

Keywords

Aromatic hydrazides, Pyrazole, QSAR Study, Green chemistry, Thiazines, Hydrazides, Microwave Irradiation

Cite This Article

Kapase, V. S., Khot, S., & Dhongade, S. R. (2014). Microwave Assisted Synthesis & QSAR Study of Some Novel Pyrazole Thioamide Derivatives. International Journal for Pharmaceutical Research Scholars, 3(1), 243-250.