Pharmaceutical Development and Pharmacokinetic Evaluation of Gastroretentive Floating Matrix Tablets of Ciprofloxacin

Author(s)

Wesley, J. I., Anisree, G. S., Ramasamy, C.

Author's Affiliation

Abstract

The most common approach for achieving sustained drug release is done by the use of hydrophilic polymers into tablets. Hydrophilic polymers swell in the presence of water to form hydrogel structures from which drugs are released in a slow pattern by the mechanism of diffusion. The purpose of this study was to prepare gastroretentive drug delivery of the fluroquinolone antibiotic, ciprofloxacin utilizing the mechanism of floating drug delivery. Ciprofloxacin is highly soluble in acidic medium and precipitates in alkaline media. The fabrication was done to enhance bioavailability of ciprofloxacin by retaining them in the acidic environment of the stomach. Tablets were prepared by the direct compression technique using polymers and gas generating agents. Tablets were evaluated for their physical characteristics such as hardness, thickness, friability, weight variation, drug content and floating properties. The developed tablets were evaluated by in-vitro dissolution studies. Formulations showed a floating lag time of 30 seconds and a floating time above 12 hours.

Keywords

Gastro Retentive Drug Delivery System, Ciprofloxacin, In-Vitro Studies

Cite This Article

Wesley, J. I., Anisree, G. S., & Ramasamy, C. (2014). Pharmaceutical Development and Pharmacokinetic Evaluation of Gastroretentive Floating Matrix Tablets of Ciprofloxacin. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 614-621.