Dhanga, N. K., Patel, A. N., Vyas, J. V., Upadhyay, U. M.
The objective of this study was to prepare and characterize a stable microemulsion system for encapsulating a Parathyroid hormone (PTH). To get the therapeutic amount PTH loaded into the microemulsion system without compromising the stability of microemulsion system, the key objective of this work was to solubilize higher percentage of aqueous phase loading with taste masking agent. (≥25%). Preformulation studies have been performed to prepare ternary phase diagram for surfactants, oils, co surfactants. Some of the critical parameters like proportion of surfactant and co-solvent, and speed of stirring were optimized to get maximum loading efficiency and in vitro drug release. The results of the study had conclusively demonstrated that batch F22 has given 92 % of drug release within two hour and was stable for minimum 95 days with 35.61% loading after 95 days.
Protein, Microemulsion, Parathyroid Hormone, Capmul MCM, Nasal Delivery
Cite This Article
Dhanga, N. K., Patel, A. N., Vyas, J. V., & Upadhyay, U. M. (2014). Preparation and Characterization of Protein Loaded Microemulsion for Nasal Delivery System. International Journal for Pharmaceutical Research Scholars (IJPRS),3(2), 458-465.