Review on Solid Lipid Nanoparticles

Author(s)

Abhang, R.R., Kumar, R.S., Madagul, J., Valte, Y.B., Aher, S.B.

Author's Affiliation

Abstract

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. This paper gives an overview about the potential advantages and also the disadvantages of solid lipid nanoparticles, and all the different methods involved in their production. SLN Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. The present study focuses on the preparation of SLN for increasing permeability and enhancing bioavailability. In this study use of lipophilic lipid or hydrophilic drug and excipient co-surfactant, surfactant, solvent use. Nanoparticles where prepared by cold homogenization method and evaluate for it’s particle size, entrapment efficiency, in-vitro drug release and permeability.

Keywords

SLN (solid lipid nanoparticle), LDC (lipid drug conjugation)

Cite This Article

Abhang, R.R., Kumar, R.S., Madagul, J., Valte, Y.B., Aher, S.B. (2015). Review on Solid Lipid Nanoparticles. International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 208-301.