Role of Corticosteroid and CNS Neurotransmitters in Correlation between Diabetes and Depression

Author(s)

Arun, K.S., Deshpande, S., Priyanshee, G.

Author's Affiliation

Abstract

Diabetes and Depression are highly prevalent conditions with severe impact on health outcomes. It was found that the prevalence of depression was significantly higher among patient with type 2 diabetes (T2D) but an exact mechanistic link between these two diseases is not yet clear. HPA axis hyperactivity leads to hypercortisolemia and alteration in corticosteroid metabolism which may play a key role in the development of depression in diabetes. Objective: To study the role of Corticosteroids in depressive diabetic mice. Materials and method: Total six groups each having six animal. T2D was induced by High Fat Diet (HFD) and Streptozotocin (STZ) (10 mg Kg-1, i.p.). Depression was induced by changing light & dark cycle (22:02 hr). Mifepristone (100 mg Kg-1, p.o., b.i.d.) was administered on day 49 to 53. FBG, Corticosterone level, and Forced Swimming test were performed to judge the status of the disease. Neurotransmitters level were also measured at the end of a study. Results: Serum Corticosterone, as well as Fasting Blood Glucose (FBG) level, was significant increases in diabetic, depressive and depressive diabetic group while decrease FBG level and serum corticosterone in mifepristone treated group. Immobility was significantly increased in depressive and depressive diabetic group and significantly decrease in Mifepristone received animals. Conclusion: It was concluded that Corticosteroids might be a link between diabetes and depression.

Keywords

Diabetes, depression, corticosterone, fasting blood glucose level, mifepristone

Cite This Article

Arun, K.S., Deshpande, S., Priyanshee, G. (2017). Role of Corticosteroid and CNS Neurotransmitters in Correlation between Diabetes and Depression. International Journal for Pharmaceutical Research Scholars (IJPRS), 6(3), 01 - 11.