Self-Micro Emulsifying Drug Delivery System (SMEDDS): A Novel Approach for Enhancement of Oral Bioavailability of Poorly Soluble Drugs

Author(s)

Panola, R., Mishra, A., Chauhan, C.S., Kansara, H.

Author's Affiliation

Abstract

The ability of Self Micro-emulsifying Drug Delivery Systems (SMEDDS) is to improve solubility, dissolution rate and bioavailability of a poorly water-soluble drug as there is steady increase in number of pharmacological active poorly water soluble compound. For the improvement of bio-availability of drugs with such properties, various technological strategies are reported in the literature including solid dispersions, cyclodextrines complex formation, or micronization, and different technologies of drug delivery systems. Including these approaches Self Micro-emulsifying Drug Delivery Systems (SMEDDS) have gained exposé for enhancement of oral bio-availability with reduction in dose. SMEDDS are isotropic mixtures of oil, surfactants, solvents and co-solvents/surfactants can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. It can be orally administered in soft or hard gelatin capsules. These systems form fine emulsions (or micro-emulsions) in gastro-intestinal tract (GIT), with mild agitation provided by gastric mobility.

Keywords

Self Micro-emulsifying Drug Delivery Systems, Bioavailability enhancement

Cite This Article

Panola, R., Mishra, A., Chauhan, C.S., Kansara, H. (2015). Self- Micro Emulsifying Drug Delivery System (SMEDDS): A Novel Approach for Enhancement of Oral Bioavailability of Poorly Soluble Drugs, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 492-505.