Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique

Author(s)

Patel, K.D., Patil, S.T., Pawar, S.P., Rane, B.R.

Author's Affiliation

Abstract

The  objective  of  the  research  project  is  the  enhancement  of  the  solubility  of Acyclovir  by  using  solid  dispersion  technique.  The polymers used were Polyethylene glycol (PEG 6000) and Mannitol and solid dispersions were prepared by hot melt method and kneading method. The phase solubility study was carried out to study the effect of polymers on solubility of Acyclovir. The prepared solid dispersions were characterized by Fourier transform Infrared spectroscopy (FT-IR) to identify the physicochemical interaction between drug and polymers. The dissolution studies of solid dispersion were performed by using USP II apparatus (paddle type). The dissolution studies were carried out in pH 1.2 and pH 7.4 medium. The two methods were used, the hot melt method (1:3 %w/w) prepared by using  PEG6000 showed highest percentage drug release (101.89%) as compared to kneading method in pH 1.2. Thus, the solid dispersion technique can be successfully used for improvement of solubility of Acyclovir.

Keywords

Solid Dispersion, Acyclovir, PEG 6000, Mannitol, Hot Melt Method, Solubility Enhancement

Cite This Article

Patel, K.D., Patil, S.T., Pawar, S.P., Rane, B.R. (2016). Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(3), 43-46.