Spectrophotometric Determination of Drugs in Bulk and Pharmaceutical Dosage Forms by Forming CT Complexes with DDQ

Author(s)

Sujatha, G., Swami, P.Y., Venkateshwarlu, G.

Author's Affiliation

Abstract

A simple and sensitive UV-Visible spectrophotometric method is described for the estimation of four drugs viz., Brinzolamide, Olanzapine, Donepezil and Vilazodone in their pure form as well as in some method of pharmaceutical dosage forms using Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as analytical reagent. The formation of charge transfer complexes of drugs as n-electron donor with DDQ as π-acceptor is the basis for determination of drugs. Acetonitrile was found to be suitable solvent for the analysis. The methods have been validated in terms of ICH guidelines. Under the optimized experimental conditions, Beer’s law is obeyed over the concentration ranges of 14-84 µg/ml, 2-12 µg/ml, 90-540 µg/ml and 20-120 µg/ml for Brinzolamide, Olanzapine, Donepezil and Vilazodone respectively. The proposed methods for applied to the determination of the cited drug both in bulk and pharmaceutical preparation.

Keywords

Spectrophotometry, DDQ, Drugs, Quantification, Validation

Cite This Article

Sujatha, G., Swami, P.Y., Venkateshwarlu, G. (2017). Spectrophotometric Determination of Drugs in Bulk and Pharmaceutical Dosage Forms by Forming CT Complexes with DDQ. International Journal for Pharmaceutical Research Scholars (IJPRS), 6(1), 1-10.