Chaudhari, B. G., Patel, N. U., Patel, D. B.
A simple, rapid, accurate and precise assay procedure based on Spectrophotometric method has been developed for the estimation of Tamsulosin hydrochloride in Pharmaceutical formulation. The method was based on the bromination of Tamsulosin hydrochloride with a known excess amount of Bromate-bromide mixture in acidic medium followed by the determination of surplus bromine by reacting with dye methyl orange and measuring the absorbance at 513 nm. Validation was carried out in compliance with International Conference on Harmonization guidelines. Linear regression analysis of method showed good linearity with the correlation co-efficient (r) of 0.9978 with respect to absorbance in the concentration range of 2-12 μg/mL and the mean recovery for Tamsulosin hydrochloride was 99.65% ± 0.47 . The proposed method can be successfully applied for the analysis of tablet formulations.
Tamsulosin hydrochloride, Spectrophotometry, Bromination
Cite This Article
Chaudhari, B. G., Patel, N. U., & Patel, D. B. (2012). Spectrophotometric Method for Estimation of Tamsulosin Hydrochloride in Pharmaceutical Dosage Form Using Bromate-Bromide and Methyl Orange Reagent, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 104-111.