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Study of Novel Pyrrole Derivatives


Prasad, A., Nimavat, K. S., Vyas, K. B.

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Substituted benzaldehydes on simplistic condensation with 2-(5-((naphthalen-1-yloxy) methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)aceto hydrazide(1)  was give the consequent N'-arylidene-2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) aceto hydrazide (2a-e) in fine yield. Cyclo condensation of compounds (2a-e) with maleic anhydride yields 2-aryl-5-oxo-1-(2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetamido)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.


2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)aceto hydrazide, pyrrole, antibacterial and antifungal activities

Cite This Article

Prasad, A., Nimavat, K. S., Vyas, K. B. (2012). Study of Novel Pyrrole Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 16-21.

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