Synthesis and Evaluation of Poly (Acrylamide-Co-Acrylic Acid) Hydrogel for Intestinal Delivery of the Drug Naproxen Sodium

Author(s)

Menon, D., Chauhan, D., Bhitre, M.

Author's Affiliation

Abstract

Hydrogels are three dimensional polymeric networks. They have the capability to imbibe large amounts of water which results in swelling of the hydrogels. They resemble biological tissue because of their high water content. They are capable of responding to various stimuli such as temperature, pH, light, glucose, electric stimuli etc. The purpose of the research was to synthesize pH sensitive hydrogel for drug release into the intestine. pH sensitive Poly (Acrylamide-co-acrylic acid) hydrogel, poly(AAm-co-AA), was synthesized by free radical crosslinking copolymerization method. N,N’-Methylene bisacrylamide (MBAAm) was used as crosslinking agent. A combination of Ammonium persulphate (APS) and Sodium metabisulphite was used as redox initiators. Naproxen sodium was the drug incorporated into the synthesized hydrogel. The hydrogels were evaluated by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), drug loading, dynamic swelling and dissolution parameters.

Keywords

Hydrogel, Poly (Acrylamide-Co-Acrylic Acid), pH Sensitive, Naproxen Sodium

Cite This Article

Menon, D., Chauhan, D., & Bhitre, M. (2014). Synthesis and Evaluation of Poly (Acrylamide-Co-Acrylic Acid) Hydrogel for Intestinal Delivery of the Drug Naproxen Sodium. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 174-181.