Synthesis, Characterization and Antimicrobial Activity of 2-hydroxy-5-bromo-4-methoxy-N-(substituted phenyl) chalconeimine

Author(s)

Patil, S., Utale, P., Gholse, S., Pande, S., Thakur, S.

Author's Affiliation

Abstract

A series of 2-hydroxy-5-bromo-4-methoxy-N-(substituted phenyl) chalconeimine was synthesized, characterized and tested for their antimicrobial activity. These new derivative was achieved by treating 2-hydroxy-5-bromo-4-methoxy chalcone with substituted aniline at reflux temperature using ethanol as solvent in presence of H₂SO₄. Structures of the synthesized compounds were characterized using IR, ¹H-NMR and mass spectroscopy. The synthesized compounds were screened for their in vitro antibacterial activity against bacteria S. aureus, E. coli, P. aeruginosa and S. Pyogenes. And antifungal activity against C. Albicans and A.Clavatus some of these compounds exhibited moderate to good activity.

Keywords

Chalconeimines, antimicrobial activity, substituted aniline

Cite This Article

Patil, S., Utale, P., Gholse, S., Pande, S., Thakur. S. (2013), Synthesis, Characterization and Antimicrobial Activity of 2-hydroxy-5-bromo-4-methoxy-N-(substituted phenyl) chalconeimine, International Journal for Pharmaceutical Research Scholars, 2013, 2(2), 129-135.