Bhatt, N. D., Nimavat, K. S.
A series of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate derivatives of amino acids (3a-e) was synthesized. These new derivative was achieved by treating Isonipecotic acid methyl ester (1) with Boc-protected amino acids (2a-e) using CDI as coupling reagent in MDC at room temperature. Further deprotection with HCl/Dioxane gives the desired product. Structures of the synthesized compounds were established on the basis of spectral and elemental analysis. The synthesized compounds were screened for antimicrobial activity.
Protected amino acid, Isonipecotic acid, CDI, antimicrobial activity
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Bhatt, N. D., Nimavat, K. S. (2012). Synthesis, Characterization and Antimicrobial Activity of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(2), 11-15.