Synthesis, Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-nitro Benzoic acid and its Metal Complexes

Author(s)

Prasad, A. V. G. S., Rao, P. V., Prasad, P. S. S.

Author's Affiliation

Abstract

In the present study an intermolecular reductive Schiff base formation from nitro derivative and benzaldehydes is carried out in the presence of iron powder and dilute acid. Schiff base has been synthesized from 3-ethoxy salicylaldehyde and 2-nitro benzoic acid. Metal complexes of the Schiff base were also prepared from salts of Ni (II), Co (II) Cu (II) and Zn (II) in an alcoholic medium. The chemical structures of the Schiff-base ligand and its metal complexes were confirmed by various spectroscopic studies. On the basis of elemental and spectral studies, six-coordinated geometry was assigned to these complexes. It is suggested that this ligand acts as neutral and tridentate and coordinates to each metal atom by azomethine nitrogen and oxygen atoms of hydroxyl group of the 3-ethoxy salicylaldehyde. The free Schiff base and its complexes have been tested for their antibacterial as well as antifungal activity by using disc diffusion method and the results discussed. The experimental results suggest that Schiff base derivatives are more potent in antibacterial and antifungal activities.

Keywords

Schiff base, 3-ethoxy salicylaldehyde, 2-nitro benzoic acid, Metal complexes, Antibacterial activity, Antifungal activity

Cite This Article

Prasad, A. V. G. S., Rao, V. A., & Prasad, P. S. S. (2014). Synthesis, Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-nitro Benzoic acid and its Metal Complexes. International Journal for Pharmaceutical Research Scholars, 3(1), 79-85.