Baldev, A. D., Borisagar, M. G., Vyas, K. B., Nimavat, K. S.
During the last two decades, several pyrimidine derivatives have been developed as chemotherapeutic agents and have found wide clinical applications. We synthesize some pyrimidines by Biginelli condensation method. Novel 1,2,3,4-tetrahydro-N-(substitutedphenyl)-6-methyl-4-(4-(phenoxymethyl)phenyl)-2-thioxopyrimidine-5-carboxamide (AB116 to AB130) are synthesized and characterized by FT-IR, 1H NMR, Mass spectra, TLC and elemental analysis. The newly synthesized compounds were screened for antimicrobial activities(MIC) in vitro against two strains of gram –ve and two strains of gram +ve bacteria and three fungi by broth dilution method. Few of the compounds show excellent antimicrobial activity.
1,2,3,4-tetrahydro pyrimidine, Antimicrobial activity
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Baldev, A. D., Borisagar, M. G., Vyas, K. B., Nimavat, K. S. (2012). Synthesis of Novel 1,2,3,4-Tetrahydro-N-(Substitutedphenyl)-6-Methyl-4-(4-(Phenoxymethyl)Phenyl)-2-Thioxopyrimidine-5-Carboxamide and Study of their Antimicrobial Activity, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 48-55.